**Christina Applegate is facing a battle more challenging than any role she’s ever played.**

**The “Dead to Me” star, 52, opened up about her profound struggle with depression due to her multiple sclerosis diagnosis.**

**In a candid episode of her and Jamie-Lynn Sigler’s “MeSsy” podcast, she revealed, “I’m in a depression right now, which I don’t think I’ve felt that for years.”**

**Applegate described her current state as a “real, f–k-it-all depression” that is scaring her with its fatalistic feelings.**

**She admitted, “I’m trapped in, like, this darkness right now that I haven’t felt [in], like, I don’t even know how long, probably 20-something years.”**

**This raw confession came after a surprise appearance at the 2024 Emmy Awards, where Applegate received a standing ovation.**

**Despite the accolades, she confessed that the event was “the hardest day” of her life, leaving her so drained she spent the next two days sleeping.**

**“This is being really honest … I don’t enjoy living,” she shared with heartbreaking candor.**

**“I don’t enjoy it. I don’t enjoy things anymore.”**

**Jamie-Lynn Sigler, who has been battling MS for over 20 years, was quick to acknowledge the harsh reality of living in a “disabled body.”**

**However, she refused to let Applegate give up.**

**“Once we get you to this place where we’re accepting that this is how it’s going to be, maybe forever …[coping with MS] is not a reason enough for you to stop living,” Sigler said.**

**“I sit here across from you, and you still make me laugh like nobody else can. You still make me smile. You make me feel loved. I can’t let you give up. I can’t. I need you to do it for me.”**

**Applegate’s journey with MS, a debilitating disease that affects the central nervous system, has been a difficult one.**

**First diagnosed in 2021, she has been open about the physical and emotional toll it has taken.**

**MS can lead to a wide range of symptoms, from physical disabilities to cognitive challenges, making daily life a constant struggle.**

“Hi friends. A few months ago I was diagnosed with MS,” she wrote back in 2021. “It’s been a strange journey. But I have been so supported by people that I know who also have this condition.

**For someone who has spent decades in the spotlight, the shift has been particularly jarring.**

**Applegate’s career has spanned over three decades, starting with her iconic role as Kelly Bundy on “Married… with Children.”**

**She later starred in hit films like “Anchorman” and “The Sweetest Thing,” showcasing her versatility and comedic talent.**

**More recently, her role in “Dead to Me” earned her critical acclaim and a dedicated fanbase.**

**However, behind the scenes, she has been fighting an unseen battle.**

**The shock of her MS diagnosis turned her world upside down.**

**What many don’t realize is the extent of the mental health struggles that accompany such a life-altering condition.**

**Depression and anxiety are common among those with chronic illnesses, as they cope with the loss of their former selves and the uncertainty of their futures.**

Applegate’s admission to fearing therapy highlights a significant barrier many face in seeking help.

**“I’m so afraid for those floodgates to open and that I won’t be able to stop,” she confessed, revealing her apprehension about confronting her emotions.**

**The fear of being overwhelmed by pain and grief is a familiar one for many in similar situations.**

**Yet, seeking therapy can be a crucial step towards healing and managing mental health.**

**Applegate’s honesty has struck a chord with many who are silently battling their own demons.**

**Her willingness to speak out brings much-needed attention to the mental health challenges faced by those with chronic illnesses.**

**It also underscores the importance of support systems and open conversations about mental health.**

**The resilience and strength it takes to face such challenges head-on are immense.**

**Applegate’s story is a reminder of the human capacity for endurance, even in the darkest times.**

**While her current state is deeply concerning, her resolve to reconnect with her therapist offers a glimmer of hope.**

**The bond between Applegate and Sigler is a testament to the power of friendship and solidarity.**

**Sigler’s words of encouragement reflect the deep empathy and understanding shared by those who face similar struggles.**

**“You make me feel loved. I can’t let you give up,” Sigler’s plea is a powerful reminder of the impact we have on each other’s lives.**

**As Applegate navigates this difficult period, her bravery in sharing her story shines a light on an often-overlooked aspect of chronic illness.**
**Depression is a formidable foe, but with the right support and treatment, there is a path forward.**

**Christina Applegate’s journey is far from over.**

**Her openness and vulnerability offer a beacon of hope to others facing similar battles.**

**The fight against MS and depression is relentless, but it’s a fight that must continue.**

**In sharing her struggle, Applegate helps to break down the stigma surrounding mental health and chronic illness.**

**Her story is a powerful call to action for empathy, understanding, and support.**

**For now, Applegate’s fans and loved ones can only hope that her path leads to a place of healing and renewed strength.**