Tributes have already begun pouring out for the amazing character actor.
Really sad news #ClarkMiddleton— Doadre (@Doadre)1601980352.0
I will miss seeing him on #TheBlacklist so, so much :( #RIP #ClarkMiddleton— Silke (@Silke)1601973519.0
Diminutive in size but certainly not talent or heart #ClarkMiddleton r.i.p. sir + sincere sympathy Missus Middleton💜 https://t.co/yrpQmYDyVk— Maxwell Caulfield (@Maxwell Caulfield)1601960392.0
RIP Jellybean! #ClarkMiddleton— Rathin Rao (@Rathin Rao)1601955004.0
So sad to hear the news about #ClarkMiddleton 😞He was a lovely man and a fabulous actor. @sparkymiddleton RIP Clark ♥️— Debra Whitfield (@Debra Whitfield)1601983658.0
Rest In Peace Clark Middleton 🙏#TheBlacklist #ClarkMiddleton— Dr. Coconut (@Dr. Coconut)1601952962.0
No more sparring w/ Raymond Reddington, I just can't ... What a blow. Amazing man. RIP #ClarkMiddleton— Liza👩🏻🦽🐈🏔🏔 (@Liza👩🏻🦽🐈🏔🏔)1601974038.0
@AmirArison I am so sad. I don't think I can take much more this year. This is unbelievable. I am also devastate… https://t.co/ikfC5R6lMS— A Timeless Flight (@A Timeless Flight)1601944392.0
#RIP #ClarkMiddleton one of my favorites in #blacklist. Condolences to all his family and friends. 🌹 https://t.co/6Ie5m7pqoF— Maymunah (@Maymunah)1601965202.0
Rest in peace #ClarkMiddleton. You were absolutely hilarious on #theblacklist. Had me laughing every episode you were on. A unique talent.— Chibi- (@Chibi-)1601961458.0
My heart is broken. My thoughts are with his family and friends. #ClarkMiddleton. Awesome actor writer director. Th… https://t.co/z0pFm42dUz— Gypsy13 Ⓥ (@Gypsy13 Ⓥ)1601953163.0
I’m really sad to hear about the passing of #ClarkMiddleton. I love him in TheBlacklist. My thoughts are with every… https://t.co/TpDn9GpsNY— Tobias (@Tobias)1601982255.0
Oh man, what a talent. RIP #ClarkMiddleton https://t.co/jvFrRMxS0J— Trëy (@Trëy)1601952424.0
Saddened by the death of #ClarkMiddleton, so great as Glen on @NBCBlacklist.— Jim Bessman (@Jim Bessman)1601984333.0
RIP Clark Middleton -- what a gem of an actor. I could watch his scenes with James Spader for hours.— Matt Carter (@Matt Carter)1601943463.0
RIP Clark Middleton. You were amazing in all you did, from Fringe to Blacklist.— Ben and Alex (@Ben and Alex)1601985645.0
The only person that couldake Red lose his mind. RIP Clark Middleton https://t.co/gmti9VWTfx— Mentalist 🇰🇪 (@Mentalist 🇰🇪)1601981402.0
I still can't wrap my head around the fact that Clark Middleton's gone.— Hans (@Hans)1601957308.0
I am beyond heartbroken & devastated to learn that Clark Middleton (Glen Jelly Bean Carter) has passed away! What i… https://t.co/LvKG6UTUEw— Jeannie Johnson (@Jeannie Johnson)1601943037.0
Clark was a passionate advocate for and a proud member of both the 25% of the US with a disability, and the 54M Ame… https://t.co/K0zxP1XvtW— Clark Middleton (@Clark Middleton)1601970935.0
Beloved actor Clark Middleton has sadly passed away.
via: Getty ImagesHis death was confirmed by his wife, Elissa, today.
Middleton had a very impressive resume...
via: Getty ImagesIncluding roles on Twin Peaks, The Path, and The Blacklist.
Middleton had suffered from juvenile rheumatoid arthritis since he was 4 years old.
via: Getty ImagesAnd had been open about his struggles.
"At first it distorted my hands."
via: Getty Images"Then the cortisone I had to take made my cheeks fat," he explained.
"At 8, I lost movement in my neck."
via: Getty Images"When I was 15, my hip snapped."
"After an operation, I had to be on crutches."
via: Getty Images"And later, after I broke my leg falling over my dog, on canes."
Middleton even performed a 1997 one-person play called Miracle Mile.
via: Getty ImagesIn which he detailed his struggles with juvenile rheumatoid arthritis.
Alongside his television roles...
via: Getty ImahesMiddleton also enjoyed movie roles in Serendipity, Kill Bill Vol. 2, Sin City, Taking Woodstock and more.
Tributes have begun pouring in for the star.
via: Getty ImagesIncluding from past co-star Aaron Paul, who said, "Clark Middleton loved to act more than anyone I have ever met in my life and he was damn good at it. I had the privilege to work with him for many years and became dear friends with him through the process. He loved people and he knew movies. Like nobody I have ever met before."
RIP Clark Middleton...— Mary Reber (@Mary Reber)1601943429.0
"He loved movies and TV and was proud to be in this business. He was a fighter and a beautiful one at that. He always kept his head up no matter the circumstances. What a gift it was to be in his presence and learn just a little bit from him. My friend. My beautiful friend."
via: Getty Images"I love you and I miss you. Thank you for showing me what strength really looks like. Thank you for giving it your all no matter what. I hate that I am writing this right now. I don’t know what else to do. Rest In Peace you wonderful man you."
And that's not all.
via: Getty ImagesThe Blacklist creator Jon Bokenkamp also issued an emotional statement.
"I’m heartbroken. Besides being a truly unique and gifted actor, Clark was simply an incredible guy in every way. He was a whip-smart film nut."
via: Getty Images"He loved his work with a passion. And he was insanely generous of spirit … I know his entire family at The Blacklist is devastated by this news. Clark was one of the good ones, and we lost him way too soon."
And that's not all.
via: Getty ImagesMany fans have offered up words of respect and sadness for the star.
His death was announced by his wife, Elissa.
via: Getty Images"With heavy hearts we announce the passing of a life eminently worthy of celebration: Clark Tinsley Middleton, 63 – beloved actor, writer, director, teacher, hero, husband, beacon, friend."
"Clark transitioned on October 4th as a result of West Nile Virus, for which there is no known cure."
via: Getty Images"Clark was a beautiful soul who spent a lifetime defying limits and advocating for people with disabilities."
West Nile virus is transmitted mainly through mosquitoes.
via: ShutterstockIt is the leading cause of mosquito-borne disease in the United States.
Clark is survived by his wife Elissa, brother Kirby Middleton and mother Sue Perior.
via: Getty ImagesThe Arthritis Foundation has also set up the Clark Middleton Memorial Fund following his passing.
RIP to the star.
via: Getty ImagesAnd tragically, Middleton isn't the only talent we've lost this year...